Stable axial-rich chair conformer of myo-inositol derivatives due to introduction of two adjacent bulky silyl protections |
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| Authors: | Hidetoshi Yamada Kotaro Okajima Tatsuya Mukae Mugio Nishizawa |
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| Institution: | a School of Science and Technology, Kwansei Gakuin University, 2-1 Gakuen, Sanda 669-1337, Japan
b Faculty of Pharmaceutical Sciences, Tokushima Bunri University, 180 Nishihamaboji, Tokushima 770-8514, Japan |
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| Abstract: | The ring-conformational change of myo-inositol derivatives by introducing two tert-butyldimethylsilyl, triisopropylsilyl, or tert-butyldiphenylsilyl groups into the 1,2-trans hydroxy groups--3,4- and 4,5-positions--were investigated. The cyclohexane cores of the 4,5-bis-O-silylated derivatives with tert-butyldiphenylsilyl or triisopropylsilyl groups were present in the axial-rich chair form. |
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| Keywords: | Ring conformation myo-Inositol Axial-rich chair Silyl protecting groups |
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