The remarkable role of water during the chemoselective reduction of ketones mediated by metallic aluminium |
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| Authors: | Sanjay Bhar Sharmistha Guha |
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| Affiliation: | Department of Chemistry, Organic Chemistry Section, Jadavpur University, Kolkata 700032, India |
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| Abstract: | ![]()
Diaryl ketones are reduced selectively to the corresponding benzhydrols in good yield by aluminium powder in the presence of sodium hydroxide in the solvent system MeOH:H2O=2:1 whereas dialkyl ketones, α-tetralone, aryl alkyl ketones and cycloalkanones remain mostly unaffected. Interestingly, diaryl ketones remain totally unchanged by the present reagent combination in the absence of water, that is in anhydrous methanol. |
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| Keywords: | Solvents and solvent effects Reduction Aluminium and compounds |
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