Efficient and selective Stille cross-coupling of benzylic and allylic bromides using bromobis(triphenylphosphine)(N-succinimide)palladium(II) |
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Authors: | Catherine M Crawforth Richard JK Taylor |
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Institution: | Department of Chemistry, University of York, Heslington, York YO10 5DD, UK |
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Abstract: | Allylic and benzylic bromides are cross-coupled with organostannanes efficiently using the precatalyst Pd(NCOC2H4CO)(PPh3)2Br] 1. Significantly, these reactions do not require the use of hexamethylphosphoramide (HMPA) as the solvent, or additional ligands, such as trifurylphosphine or triphenylarsine. Selectivity for benzyl bromide over bromobenzene is observed for precatalyst 1, against the precatalysts, bromobis(triphenylphosphine)(benzyl)palladium(II) and bis(triphenylphosphine)palladium(II) bromide. |
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