MR imaging of non-cancerous hepatic lesions in Long-Evans Cinnamon rats |
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| Institution: | 1. National Institute for Environmental Studies, Onogawa, Tsukuba, Ibaraki 305, Japan;2. Department of Radiology, Institute of Clinical Medicine, University of Tsukuba, Tsukuba, Ibaraki 305, Japan;3. Department of Pathology, Tsukuba Medical Center, Tsukuba, Ibaraki 305, Japan;1. University of Southampton, School of Ocean and Earth Science, Southampton, SO14 3ZH, UK;2. Ghent University, Department of Geology, PProGRess/UGCT, Ghent, Belgium;3. University of Grenoble Alpes, ISTerre, Grenoble, France;4. GEOMAR Helmholtz-Centre for Ocean Research Kiel, Kiel, Germany;5. National Oceanography Centre, Waterfront Campus, Southampton, SO14 3ZH, UK;1. SWM Consulting, 9 Clearview Dr, Wallingford, CT 06492, USA;2. Dpt of Pediatrics, College of Medicine, University of Tennessee Center for Health Sciences, Memphis, TN, USA;3. Dpt of Microbiology, Immunology, and Biochemistry, College of Medicine, University of Tennessee Center for Health Sciences, Memphis, TN, USA;4. Children’s Foundation Research Institute at Le Bonheur Children''s Hospital, Memphis, TN, USA;5. Ark Bisociences Inc, Basel, Switzerland;6. Ark Biosciences Inc, Shanghai, PR China;7. Department of Pediatrics, Microbiology, Medicine and Neurosurgery, The University of Alabama at Birmingham, USA;1. State Key Laboratory for Novel Software Technology, Nanjing University, Nanjing, China;2. Department of Computer Science and Technology, Nanjing University, Nanjing, China;3. School of Mobile Internet, Taizhou Institute of Sci. and Tech., NUST, Taizhou, China;4. School of Communication Engineering, Nanjing Institute of Technology, Nanjing, China;5. School of Earth Sciences and Engineering, Nanjing University, Nanjing, China |
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| Abstract: | We measured MR images of the liver of Long-Evans Cinnamon (LEC) rats with pathologic correlation and assessed the effectiveness of MR imaging (MRI) for diagnosis of noncancerous hepatic lesions. T1- and T2-weighted images of their livers were obtained, and the dynamic and delayed studies after intravenous gadolinium injection were also performed. Cholangiofibrosis showed low signal intensity on T1-weighted images and high signal intensity on T2-weighted images. The T2 relaxation time of cholangiofibrosis was significantly prolonged (p < .01), and the signal intensity ratio of this lesion to muscle on T1-weighted images was significantly lower than that of normal liver parenchyma to muscle (p < .01). The lesion was enhanced immediately after gadolinium injection and the enhancement was prolonged. Among three cases of peliosis hepatis identified, one showed heterogeneous intensities on both T1- and T2-weighted images and the other two showed similar intensity pattern to cholangiofibrosis. The characteristic MR appearance of cholangiofibrosis may be useful to distinguish it from hepatocellular carcinoma (HCC). |
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