| L-卡尼丁分子压印聚合物作为手性分离色谱固定相的研究 |
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| 引用本文： | 李晓桃,蒋光光,史月华,徐铸德.L-卡尼丁分子压印聚合物作为手性分离色谱固定相的研究[J].分析化学,2002,30(4):388-391. |
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| 作者姓名： | 李晓桃 蒋光光 史月华 徐铸德 |
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| 作者单位： | 1. 浙江大学化学系,杭州,310027
2. 浙江大学化工系,杭州,310027 |
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| 基金项目： | 浙江省分析测试基金资助项目 (No .0 0 12 6) |
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| 摘 要： | 以L－卡尼丁为模板分子，分别以α－甲基丙烯酸和丙烯酰胺为功能单体，乙二醇二甲基丙烯酸酯为 剂，采用分子压印技术合成了对L－卡尼丁具有高选择性的分子压印聚合物。将所得聚合物用作高效液相色谱固定相，研究了它们对外消旋卡尼丁盐酸盐的拆分能力，分析结果表明，α－甲基丙烯酸作为功能单体所得聚合物对外消旋卡尼丁盐酸盐具有良好的拆分作用，其分离因子α为1．89。
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| 关 键 词： | L－卡尼丁 分子压印聚合物 手性分离 固定相 外消旋卡尼丁盐酸盐 高效液相色谱 |
Non-covalently Molecularly Imprinted Polymer as a Chiral Stationary Phase to Resolve the Enantiomers of Carnitine Hydrochloride |
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| Li Xiaotao ,Jiang Guangguang ,Shi Yuehua ,Xu Zhude.Non-covalently Molecularly Imprinted Polymer as a Chiral Stationary Phase to Resolve the Enantiomers of Carnitine Hydrochloride[J].Chinese Journal of Analytical Chemistry,2002,30(4):388-391. |
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| Authors: | Li Xiaotao Jiang Guangguang Shi Yuehua Xu Zhude |
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| Institution: | Li Xiaotao 1,Jiang Guangguang 2,Shi Yuehua 1,Xu Zhude *1 1 |
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| Abstract: | Molecularly imprinted polymers (MIPs) were synthesized using L carnitine as the template, ethylene glycol dimethacrylate as the cross linker, methacrylic acid (MAA) and acrylicamine (AA) as the functional monomer respectively. The prepared polymers were applied as the liquid chromatographic chiral stationary phase to test their resolution ability for racemic carnitine hydrochloride. The results showed that racemic carnitine hydrochloride could be efficiently resolved on the MAA MIPs with a separation factor of 1.89. |
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| Keywords: | L Carnitine racemic carnitine hydrochloride molecularly imprinted polymer high performance liquid chromatography |
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