Vertebrate collagenase inhibitor. I. Tripeptidyl hydroxamic acids |
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| Authors: | S Odake T Okayama M Obata T Morikawa S Hattori H Hori Y Nagai |
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| Affiliation: | Research Institute, Fuji Chemical Industries, Ltd., Toyama, Japan. |
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| Abstract: | ![]()
A series of tripeptidyl analogues carrying hydroxamic acid residue at the C-terminus of the molecule were synthesized, and their inhibitory activities against vertebrate collagenase and other metalloenzymes including bacterial collagenase were examined. Both Z-Pro-Leu-Ala-NHOH and Z-Pro-D-Leu-D-Ala-NHOH showed highly specific and potent inhibitory activity against tadpole and human skin collagenases with an IC50 of 10(-6) M order. |
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