One-Pot Reduction of Carboxylic Acids via O-Acylisoureas |
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| Authors: | John M. Herbert Alan T. Hewson James E. Peace |
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| Affiliation: | 1. Isotope Chemistry Laboratories, Department of Preclinical Metabolism and Pharmacokinetics , Sanofi Research, Willowburn Ave, Alnwick, Northumberland, NE66 2JH, U.K.;2. Division of Chemistry and Health Research Institute , Sheffield-Hallam University, Pond St. , Sheffield, S1 1WB, U.K. |
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| Abstract: | ![]()
A simple one-pot reduction of aliphatic carboxylic acids to primary alcohols, by treatment with dicyclohexylcarbodiimide followed by lithium borohydride, is reported. The same methodology applied to aromatic carboxylic acids is shown to give a mixture of the alcohols with N-cyclohexylcarboxamides. |
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