The anticancer drug cisplatin can cross-link the interdomain zinc site on human albumin |
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| Authors: | Hu Wenbing Luo Qun Wu Kui Li Xianchan Wang Fuyi Chen Yi Ma Xiaoyan Wang Jianping Liu Jianan Xiong Shaoxiang Sadler Peter J |
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| Affiliation: | CAS Key Laboratory of Analytical Chemistry for Living Biosystems, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, PR China. |
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| Abstract: | ![]()
Cisplatin, cis-[Pt(Cl(2)(NH(3))(2)], can crosslink residues His67 of domain I and His247 of domain II in human albumin, occupying the major binding site for the essential metal zinc on the protein. |
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