| 化妆品中二噁烷的气相色谱-质谱分析 |
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| 引用本文： | 李艳,唐杨,梁静,罗立骏,朱照静. 化妆品中二噁烷的气相色谱-质谱分析[J]. 广州化学, 2013, 0(4): 27-30,11 |
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| 作者姓名： | 李艳 唐杨 梁静 罗立骏 朱照静 |
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| 作者单位： | [1]重庆市食品药品检验所,重庆市药物过程与质量控制工程技术研究中心重庆401121 [2]重庆医药高等专科学校,重庆400030 |
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| 摘 要： | 建立气相色谱串联质谱法鉴别并测定化妆品中二噁烷含量的方法.采用顶空进样,并建立标准曲线,计算化妆品中二噁烷的含量.方法的最低检出限为1.3 ng/g,定量限为4.3 ng/g;当标准工作液在0.026～10.35 mg/L的范围内线性良好;当加标质量浓度在0.104～1.035 mg/L的范围内,化妆品中二噁烷的回收率为89.4％～109.6％,相对标准偏差为5.7％.建立的方法能满足相关法规要求,研究结果为化妆品中二噁烷的含量测定提供了参考依据.
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| 关 键 词： | 气相色谱-质谱（GC-MS） 二噁烷 1,4-二氧六环 化妆品 |
Analysis of Dioxane in Cosmetics by Gas Chromatography-Mass Spectrometry |
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| LI Yan,TANG Yang,LIANG Jing,LUO Li-jun,ZHU Zhao-jing. Analysis of Dioxane in Cosmetics by Gas Chromatography-Mass Spectrometry[J]. Guangzhou Chemistry, 2013, 0(4): 27-30,11 |
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| Authors: | LI Yan TANG Yang LIANG Jing LUO Li-jun ZHU Zhao-jing |
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| Affiliation: | 2. ( 1. Chongqing Institute for Food and Drug Control, Chongqing Engineering Research Center for Pharmaceutical Process And Quality Control, Chongqing 401121 China 2. Chongqing Medical and Pharmaceutical College, Chongqing 400030, China) |
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| Abstract: | A method for dioxane quantitative analysis in cosmetics was developed by gas chromatography tandem mass spectrometry （GC-MS） with headspace sampling. The limits of detection （LOD） are 1.3 ng/g, and the limits of quantitation （LOQ） are 4.3 ng/g. The calibration curves are linear between 0.026-10.35 mg/L. Recoveries of dioxane in cosmetics are between 89.4% and 109.6%, and inter-relative standard deviations （n： 5） are less than 5.7% at spiked level of 0.104-1.035 mg/L. The method is simple, sensitive and reliable, and the findings provide a basis for the determination of dioxane in cosmetics. |
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| Keywords: | gas chromatography-mass spectrometry （GC-MS） dioxane 1, 4-dioxane cosmetics |
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