A new traceability scheme for the development of international system-traceable persistent organic pollutant reference materials by quantitative nuclear magnetic resonance |
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Authors: | Takeshi Saito Toshihide Ihara Masayoshi Koike Shinichi Kinugasa Yoshinori Fujimine Kazutoshi Nose Tetsuya Hirai |
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Institution: | (1) National Metrology Institute of Japan, AIST, Tsukuba, Japan;(2) Otuka Pharmaceutical Co., Ltd., Tokushima, Japan |
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Abstract: | Quantitative nuclear magnetic resonance (qNMR) was used for the purity determination of neat compounds of persistent organic
pollutants (POPs). qNMR is a unique quantitative method that is not only traceable to the International System of Units (SI),
but it also does not require a standard of its own. The purities of the POP compounds determined in this work were traceable
to a single certified reference material (CRM), which is extremely attractive for reference material producers. The purities
observed by qNMR were equivalent to those observed by gas chromatography with flame ionization detection (GC/FID) or a differential
scanning calorimetry (DSC) combined with a thermogravimetric analyzer (TGA). The uncertainties obtained by the qNMR method
were comparable to being slightly larger than those observed by DSC. |
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Keywords: | Quantitative NMR Purity determination Uncertainty Traceability POPs |
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