Highly Efficient and Versatile Synthesis of Some Important Precursors from 1,6-Anhydrous-β-D-glucopyranose as a Green Starting Material

Some important precursors (1,6-anhydrous-2-deoxy-2-azido-β-D-glucopyranose (3), 1,6-anhydrous-2-deoxy-2- azido-3,4-di-O-benzyl-β-D-mannopyranose (5), 1,6:2,3-dianhydrous-β-D-glucopyranose (6), 1,6-anhydrous-3- deoxy-3-azido-β-D-glucopyranose (10) and 1,6-anhydrous-2,4-di-O-benzoyl-β-D-glucopyranose (11)) for complex oligosaccharide synthesis were readily prepared from a green starting material 1,6-anhydrous-β-D-glucopyranose in one or two steps with moderate to high yields. These improved methods established herein will greatly facilitate the assembly of some complex oligosaccharides for the biological study.