Synthesis of β-amino-α-trifluoromethyl alcohols and their applications in organic synthesis |
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| Authors: | Grzegorz Mlostoń Emilia Obijalska |
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| Institution: | a Department of Organic and Applied Chemistry, University of ?ód?, Tamka 12, PL-91-403, ?ód?, Poland
b Institute of Organic Chemistry, University of Zurich, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland |
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| Abstract: | A comprehensive overview on methods applied for syntheses of β-amino-α-trifluoromethyl alcohols, including stereocontrolled variants, is presented. In addition, reported cases of the exploration of β-amino-α-trifluoromethyl alcohols for the preparation of trifluoromethylated peptidomimetics and other biologically active, fluorinated compounds are discussed. Attractive opportunities for their applications as organocatalysts are also presented. |
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| Keywords: | Organic synthesis Amino alcohols Fluorinated compounds Trifluoromethyl alcohols Stereocontrolled processes Biological activity |
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