Hydrazones and new Oximes of 4-Aminobicyclo[2.2.2]octanones and their Antiprotozoal Activities |
| |
Authors: | Robert Weis Marcel Kaiser Reto Brun Robert Saf and Werner Seebacher |
| |
Abstract: | 4-Aminobicyclo2.2.2]octan-2-ones and -ols showed activity against the causative organisms of East African sleeping sickness
and Malaria tropica. Several imino derivatives of the ketones were more active. Now hydrazono analogues and 3-hydroximino
derivatives of the ketones and alcohols were synthesized. The structures of the obtained isomers were elucidated by NMR spectroscopy.
A single phenylhydrazone exhibited quite good antitrypanosomal activity in the range of already known imino analogues. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |