Homozygous mutation of focal adhesion kinase in embryonic stem cell derived neurons: normal electrophysiological and morphological properties in vitro |
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| Authors: | P Charlesworth NH Komiyama SGN Grant |
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| Affiliation: | (1) Wellcome Trust Sanger Institute, CB10 1SA Hinxton, Cambridge, UK;(2) Centre for Neuroscience Research, University of Edinburgh, Edinburgh, UK |
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| Abstract: | Background Genetically manipulated embryonic stem (ES) cell derived neurons (ESNs) provide a powerful system with which to study the consequences of gene manipulation in mature, synaptically connected neurons in vitro. Here we report a study of focal adhesion kinase (FAK), which has been implicated in synapse formation and regulation of ion channels, using the ESN system to circumvent the embryonic lethality of homozygous FAK mutant mice. |
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