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Trifluoromethylation of various aromatic compounds by CF3I in the presence of Fe(II) compound, H2O2 and dimethylsulfoxide |
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| Authors: | Tatsuhito Kino Yu Nagase Kyoko Yamamoto Kenji Tokuhisa |
| Institution: | a Sagami Chemical Research Center, Hayakawa 2743-1, Ayase, Kanagawa 252-1193, Japan b Tokai University, Faculty of Engineering, Department of Applied Chemistry, Kitakaname 1117, Hiratsuka-shi, Kanagawa 259-1292, Japan c Tosoh F-Tech Inc., Kaisei-cho 4988, Shunan, Yamaguchi 746-0006, Japan |
| Abstract: | Trifluoromethylation of aromatic and hetero-aromatic compounds by CF3I in the presence of Fe(II) compound, H2O2 and dimethylsulfoxide was investigated. Various trifluoromethylated benzene derivatives, six-membered nitrogen-containing aromatic compounds and five-membered hetero-aromatic compounds were obtained under mild conditions. General orientation of electrophilic substitution of aromatic compounds was observed similarly as reported in other radical trifluoromethylation previously. |
| Keywords: | Trifluoromethylation Trifluoromethyl iodide Trifluoromethyl radical |
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