Synthesis, crystal structure and in vitro antitumor activity of carboxylate bridged dinuclear organotin(IV) complexes |
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Authors: | Zafar A Siddiqi M Shahid Sarvendra Kumar Mohd Khalid Shabana Noor |
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Institution: | Bio-inorganic Research Group, Division of Inorganic Chemistry, Department of Chemistry, Aligarh Muslim University, Aligarh, 202002, India |
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Abstract: | Two novel dinuclear organotin(IV) complexes n-Bu2Sn(imda)(H2O)]2·Bipy (1) and n-Bu2Sn(imda)(H2O)]2·Phen (2) H2imda = iminodiacetic acid, Bipy = 2,2′-bipyridine and Phen = 1,10-phenanthroline] were synthesised and characterized employing IR, 1H, 13C, 119Sn NMR, and 119Sn Mössbauer spectroscopic and elemental analyses. Single crystal X-ray crystallography of 1 has confirmed that it is a binuclear Sn(IV) species formed via carboxylate bridges where each metal adopted a seven coordinate distorted pentagonal bipyramidal geometry. The iminodiacetate dianion (imda2−) acts as a potential tridentate N,O,O] carboxylate bridging ligand. The packing revealed that the additional α-diimine (Bipy or Phen) does not coordinate to metal ion. However, its presence in the crystal lattice as spacer helps for the formation of a supramolecular framework by bringing the two binuclear species close enough through extensive H-bonding. The in vitro cytotoxicity of compounds 1 and 2 indicate better results than cisplatin against three tumor cell lines investigated. |
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Keywords: | Dinuclear organotin(IV) complexes 119Sn-NMR 119Sn-Mö ssbauer Crystal structure Cytotoxicity |
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