氨基醇AMP的合成及其催化转化研究进展

氨基醇的高效合成和催化转化是实现氨基醇在医药、农药、新材料、二氧化碳捕集等领域广泛应用的关键。综述了硝基烷烃工艺、氨基酸酯加氢、异丁烯衍生物工艺等合成2-氨基-2-甲基-1-丙醇(AMP)的方法,结合课题组研究工作,介绍了AMP催化转化合成2-甲基-1,2-丙二胺、四甲基二乙烯三胺、2,2-二甲基氮丙啶等方面的研究工作,指出了AMP高效清洁合成和催化转化今后需重点解决的问题。

Research Progress in the Synthesis and Catalytic Conversion of Amino Alcohol AMP

The efficient synthesis and catalytic conversion of amino alcohols is the key to achieving their wide application in the fields of pharmaceuticals, pesticides, new materials, carbon dioxide capture, and so on. Different methods for the synthesis of 2-amino-2-methyl-1-propanol (AMP), such as nitroalkane process, amino acid ester hydrogenation, and isobutylene derivative process, were reviewed. In combination with the research field of our research group, research work on the catalytic conversion of AMP to synthesis of 2-methyl-1,2-propanediamine, tetramethyldiethylenetriamine, and 2,2-dimethylaziridine was introduced, and the critical issues to be solved in the efficient and clean synthesis and catalytic conversion of AMP were pointed out.