| Synthesis of a novel multivalent galactoside with high hepatocyte targeting for gene delivery |
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| 作者姓名： | Qing Lin Jiang Li Hai Lei Chen Jiao Lu Zhi Rong Zhang Yong Wu |
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| 作者单位： | Key Laboratory of Drug Targeting of Education Ministry, West China School of Pharmacy, Sichuan University, Chengdu 610041, China |
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| 基金项目： | 国家自然科学基金，教育部科学技术研究项目 |
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| 摘 要： | A novel bifunctional glycolipid which carded a cluster of thiogalactosides as the hepatocyte targeting ligand for gene delivery was prepared. Hexa-antennary alcohol 1 was used as the core scaffold to attach a cholesterol molecule by a poly（ethylene glycol） chain, while its remaining branches were linked with five acetylgalactosides, which would be deacetylated later to produce pentaantennary galactoside. Liposome containing the galactoside showed high affinity and transfection activity in hepatoma cells HepG2.
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| 关 键 词： | 群生糖苷 基因传送 肝细胞 半乳糖苷 合成方法 |
| 收稿时间： | 2007-06-20 |
Synthesis of a novel multivalent galactoside with high hepatocyte targeting for gene delivery |
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| Qing Lin Jiang Li Hai Lei Chen Jiao Lu Zhi Rong Zhang Yong Wu.Synthesis of a novel multivalent galactoside with high hepatocyte targeting for gene delivery[J].Chinese Chemical Letters,2008,19(2):127-129. |
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| Authors: | Qing Lin Jiang Li Hai Lei Chen Jiao Lu Zhi Rong Zhang Yong Wu |
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| Institution: | Key Laboratory of Drug Targeting of Education Ministry, West China School of Pharmacy, Sichuan University, Chengdu 610041, China |
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| Abstract: | A novel bifunctional glycolipid which carried a cluster of thiogalactosides as the bepatocyte targeting ligand for gene delivery was prepared.Hexa-antennary alcohol 1 was used as the core scaffold to attach a cholesterol molecule by a poly(ethylene glycol)chain,while its remaining branches were linked with five acetylgalactosides,which would be deacetylated later to produce pentaantennary galaetoside.Liposome containing the galactoside showed high affinity and transfection activity in hepatoma cells HepG2. |
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| Keywords: | Clustered glycosides Targeting Galactosylated ligand Hepatocyte Gene delivery |
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