| 2-氰基-2,3-二甲基-3-甲基羰甲基-5-硫酮-吡咯烷的合成 |
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| 引用本文： | 胡炳成,吕春绪.2-氰基-2,3-二甲基-3-甲基羰甲基-5-硫酮-吡咯烷的合成[J].应用化学,2004,21(11):1165-1168. |
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| 作者姓名： | 胡炳成 吕春绪 |
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| 作者单位： | 南京理工大学 |
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| 摘 要： | 2-氰基-2;3-二甲基-3-甲基羰甲基-5-硫酮-吡咯烷的合成;双甲基环并内酯;双甲基环并内酰胺-内酯;氰基吡咯烷酮;氰基吡咯烷硫酮
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| 关 键 词： | 2-氰基-2 3-二甲基-3-甲基羰甲基-5-硫酮-吡咯烷的合成 双甲基环并内酯 双甲基环并内酰胺-内酯 氰基吡咯烷酮 氰基吡咯烷硫酮 |
| 文章编号： | 1000-0518(2004)11-1165-04 |
| 收稿时间： | 2009-06-29 |
| 修稿时间： | 2003年12月20 |
Synthesis of 2-Cyano-2,3-dimethyl-3-methoxycarbonyl methyl-5-thioxo-pyrrolidine |
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| HU Bing Cheng ,LU Chun Xu.Synthesis of 2-Cyano-2,3-dimethyl-3-methoxycarbonyl methyl-5-thioxo-pyrrolidine[J].Chinese Journal of Applied Chemistry,2004,21(11):1165-1168. |
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| Authors: | HU Bing Cheng LU Chun Xu |
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| Institution: | HU Bing Cheng *,LU Chun Xu |
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| Abstract: | Amination of dimethylbicyclolactam 1 gives dimethyl bicyclolactam lactone 2, which transfers to cyanopyrolidones 3a and 3b through substitutive ring opening reactions by action of hydrocyanic acid and esterification with diazomethane. Sulfidizations of 3a and 3b give the end products, cyanopyrrolidinylthiones 4a and 4b, with total yield of ca . 59%. The trans and cis isomeric products were isolated by HPLC in mass fraction of 64 5% and 34 0%, respectively. Their structures were confirmed by elemental analysis, UV Vis, IR, 1 H NMR, 13 C NMR and MS spectra. |
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| Keywords: | dimethylbicyclolactam dimethylbicyclolactam-lactone cyanopyrrolidone cyano-pyrrolidine-thione |
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