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Facile synthesis of 3-substituted quinazoline-2,4-dione and 2,3-di-substituted quinazolinone derivatives |
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| Authors: | Mahmoud Farouk Salman A Alrokayan Ahamad Imran Khalid M Abu-Salah Mohamed Ghazzali Khalid A Al-Farhan Salem El-Gohary Mamdouh Adly |
| Institution: | 1. College of Sciences & Humanity studies, Salman Bin Abdalaziz University, P. O. Box 83, Alkharj, 11942, Saudi Arabia 2. Centre of Excellence in Biotechnology Research, King Saud University, P. O. Box 2460, Riyadh, 11451, Saudi Arabia 3. Research Chair of Targeting and Treatment of Cancer Using Nanoparticles, King Abdullah Institute for Nanotechnology, King Saud University, P. O. Box 2454, Riyadh, 11451, Saudi Arabia 4. Chemistry Department, College of Science, King Saud University, P. O. Box 2455, Riyadh, 11451, Saudi Arabia 5. Chemistry Department, Faculty of Science, South Valley University, Qena, 83523, Egypt |
| Abstract: | 3-Substituted quinazoline-2,4(1H,3H)-dione and 2,3-di-substituted quinazolineone derivatives attract considerable interest due to their pharmacological properties. In this paper, we report the synthesis of N-substituted-3-nitrophthalimide derivatives II?CIII, the reactions of phthalimide III with amines, hydrazines, and amino acid derivatives to synthesise a small library of 3-substituted-5-nitroquinazoline-2,4(1H,3H)-diones IV?CXIV and 2,3-di-substituted-6-nitro-quinazolineones XVIII?CXIX. |
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