Rapid separation of acetophenone and its monohydroxy isomers by capillary electrophoresis |
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| Authors: | Ramaiyan Sekar Suresh Kumar Kailasa Wen-Shan Li Han-Chung Wu Hui-Fen Wu |
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| Affiliation: | Ramaiyan Sekar;Suresh Kumar Kailasa;Wen-Shan Li;Han-Chung Wu;Hui-Fen Wu;Department of Chemistry, National Sun Yat-Sen University;Depatment of Applied Chemistry, S.V. National Institute of Technology;Doctoral Degree Program in Marine Biotechnology, National Sun Yat-Sen University;Institute of Chemistry, Academia Sinica;Institute of Cellular and Organismic Biology, Academia Sinica;Center of Nanoscience and Nanotechnology, National Sun Yat-Sen University;School of Pharmacy, College of Pharmacy, Kaohsiung Medical University; |
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| Abstract: | This work describes the development of a capillary electrophoresis(CE) method for the simultaneous separation of acetophenone(AP), 2-hydroxyacetophenone(2-HAP), 3-hydroxyacetophenone(3-HAP) and 4-hydroxyacetophenone(4-HAP) in synthetic mixtures using 10 mmol/L of sodium tetraborate buffer(pH 9.5). The aim of this work is to demonstrate the effectiveness of CE to separate AP and its monohydroxy isomers and to define how the separations are affected by buffers, buffer pH, sample matrices and separation voltage. This method was successfully used for the trace level separation and determination of 2-HAP, 3-HAP and 4-HAP in synthetic mixture and 4-HAP in spiked plasma samples. |
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| Keywords: | Capillary electrophoresis Electrokinetic injection Acetophenone isomers Plasma |
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