Synthesis of novel copolymer:Poly(p-dioxanone-co-L-phenylalanine) |
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Authors: | Bing Wang Chi Ma Zuo-Chun Xiong Cheng-Dong Xiong Quan-Hua Zhou Dong-Liang Chen |
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Institution: | a Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu 610041, China;
b University of Chinese Academy of Sciences, Beijing 100049, China;
c Sichuan Staff University of Science and Technology, Chengdu 610041, China |
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Abstract: | In order to expand the application of poly(p-dioxanone) or PPDO in biomedical area, a series of novel copolymers were synthesized successfully by one-step, melted copolymerization of p-dioxanone (PDO) and L-phenylalanine N-carboxyanhydride (L-Phe-NCA) monomers. With the in-feedmolar ratio of L-Phe-NCA/PDO equal to 1/20, the conversions of the two kinds of monomers were calculated from 1H NMR. The average molecular weight and polydispersity of the copolymer increase with the increasing reaction time and catalyst concentration. However, the conversions of the two kinds of monomers did not change with the reaction conditions. A three-step mechanism is presented and proved by high resolution 1H NMR and IR spectrums. |
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Keywords: | Copolymer p-Dioxanone L-Phenylalanine Mechanism |
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