Platinum(II) complexes of reduced amino acid ester Schiff bases: synthesis, characterization, and antitumor activity |
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| Authors: | Li-Jun Li Cheng Wang Yu Qiao Xiao-Yan Yang Xing-Xing Hua Jian-Long Du |
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| Affiliation: | 1. Chemical Biology Key Laboratory of Hebei Province, Hebei University, Baoding, 071002, China
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| Abstract: | A series of platinum(II) complexes of reduced amino acid esters Schiff bases were synthesized as potential anticancer agents and characterized by 1H NMR, EA, IR, and molar conductivity. These compounds were tested for their DNA interaction with salmon sperm DNA by ultraviolet spectrum and CD spectrum, and their in vitro anticancer activities have been validated against HL-60, KB, BGC-823, and Bel-7402 cell lines by MTT assay. The cytotoxicity of complexes 5d and 5f are better than cisplatin against Bel-7402 cell lines, and show a close cytotoxic effect against HL-60 cell line. |
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