Flow-Injection Fluorometric Determination of Novalgin in Pharmaceutical Preparations

A flow-injection configuration for the fluorometric determination of Novalgin (dipyrone) is proposed. The procedure is based on the oxidation of Novalgin by cerium(IV). The fluorescence native of cerium(III) formed in the oxidation of Novalgin is monitored. Lineal calibration graphs were obtained between 0.5 and 4 μg/ml, with a sampling rate of 40 samples/h and relative standard deviations between 0.93 and 2.8%. The applicability of the method to the determination of Novalgin in pharmaceutical preparations was demonstrated by investigating the effect of potential interferences and by analysis of commercial preparations.