Studies on medicinal resources from livestock. II. Anti-allergic effects of pig bile. (2)

Anti-allergic activities of lyophilized pig bile ( PB]) were examined in mice with picryl chloride-induced contact dermatitis (PC-CD), an experimental model of delayed-type hypersensitivity (DTH; type-IV allergy). PC-CD was markedly inhibited by an oral administration of PB] within 4 h after but not during 8 to 16 h after challenge with picryl chloride. Anti-inflammatory activities of PB] were also examined in acetic acid-induced mouse increased vascular permeability, hypotonic-hyperthermic lysis of rat erythrocytes and carrageenin-induced rat hind paw edema. PB] had no effect on these models. The present study suggests that PB] inhibits PC-CD through its immuno-modulation in the inductive phase of DTH rather than by an anti-inflammatory action.