Lanostane-type triterpenoids from Kadsura coccinea |
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| Affiliation: | 1. State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, No.1 Beichenxi Road, Chaoyang District, Beijing 100101, PR China;2. Savaid Medicine School, University of Chinese Academy of Sciences, Beijing 100049, PR China;3. Emeishan Guozhitang Biological Technology Co. LTD, No. 15 Wannianxi Road, Suishan Town, Emeishan City 614000, PR China;1. Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, Faculty of Pharmacy, Tongji Medical College of Huazhong University of Science and Technology, Wuhan 430030, People''s Republic of China;2. Department of Pharmacy, Tongji Hospital, Huazhong University of Science and Technology, Wuhan 430030, People''s Republic of China |
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| Abstract: | ![]()
Systematic phytochemical investigation on the stems of Kadsura coccinea resulted in the isolation of eleven new lanostane-type triterpenoids, named kadcoccinones G–Q (1–11), together with two known structural analogues, kadpolysperin M (12) and abiesatrine D (13). Their structures were characterized on the basis of comprehensive spectroscopic methods, and the absolute configuration of 1 was ascertained by single-crystal X-ray diffraction. Structurally, compounds 1/2, 4/5, and 6/7 were three pairs of C-12 epimers, respectively. Additionally, compounds 1–11 were evaluated for their in vitro cytotoxicity against the human tumor HL-60, SMMC-772, A-549, MCF-7, SW-480, and HeLa cell lines using the MTS viability assay. |
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| Keywords: | Lanostane-type triterpenoids Cytotoxicity LGYHQPQOXJOAQF-MUUZAPTASA-N |
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