Solid-phase synthesis of 3-alkylamino-1,2,4-triazoles |
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Authors: | Makara Gergely M Ma Yao Margarida Laura |
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Affiliation: | NeoGenesis Pharmaceuticals, 840 Memorial Drive, Cambridge, Massachusetts 02139, USA. gregm@neogenesis.com |
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Abstract: | [reaction: see text] A solid-phase synthesis of trisubstituted 3-alkylamino-1,2,4-triazoles has been developed. The synthesis utilizes immobilized N-acyl-1H-benzotriazole-1-carboximidamides as key intermediates. Cyclization with hydrazines under mild conditions furnishes the title compounds with regioselectivity and high purity. |
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