Facile One‐Pot Synthesis of [1, 2, 3]Triazolo[1, 5‐a]Pyridines from 2‐Acylpyridines by Copper(II)‐Catalyzed Oxidative NN Bond Formation期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

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Facile One‐Pot Synthesis of [1, 2, 3]Triazolo[1, 5‐a]Pyridines from 2‐Acylpyridines by Copper(II)‐Catalyzed Oxidative NN Bond Formation

Authors:	Dr Tasuku Hirayama Dr Satoshi Ueda Takahiro Okada Norihiko Tsurue Prof Kensuke Okuda Prof Hideko Nagasawa

Institution:	Laboratory of Medicinal and Pharmaceutical Chemistry, Gifu Pharmaceutical University, 1‐25‐4, Daigaku‐nishi, Gifu 501‐1196 (Japan), Fax: (+81)?58‐230‐8112

Abstract:	An efficient and simple method for the synthesis of various 1, 2, 3]triazolo1, 5‐a]pyridines has been established. The method involves a copper(II)‐catalyzed oxidative N?N bond formation that uses atmospheric oxygen as the terminal oxidant following hydrazonation in one pot. The use of ethyl acetate as the solvent dramatically promotes the oxidative N?N bond‐formation reaction and enables the application of oxidative cyclization in the efficient one‐pot reaction. A mechanism for the reaction was proposed on the basis of the results of a spectroscopic study.

Keywords:	copper cyclizations hydrazones nitrogen heterocycles N N coupling