Silver‐Catalyzed Cross‐Coupling of Propargylic Alcohols with Isocyanides: An Atom‐Economical Synthesis of 2,3‐Allenamides |
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| Authors: | Jianquan Liu Zhenhua Liu Nannan Wu Dr. Peiqiu Liao Prof. Xihe Bi |
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| Affiliation: | 1. Department of Chemistry, Northeast Normal University, Changchun 130024 (China);2. State Key Laboratory of Elemento‐Organic Chemistry, Nankai University, Tianjin, 300071 (China) |
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| Abstract: | Cross‐coupling reactions between propargylic alcohols and isocyanides, by means of silver catalysis, have been described. This new reaction is both atom and step efficient and is applicable to a broad scope of substrates, allowing the synthesis of a range of synthetically valuable 2,3‐allenamides in moderate to excellent yields. |
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| Keywords: | 2,3‐allenamides cross‐coupling isocyanides propargylic alcohols silver catalysis |
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