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PdII‐Catalyzed Mild CH ortho Arylation and Intramolecular Amination Oriented by a Phosphinamide Group |
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| Authors: | Jing Guan Guo‐Jie Wu Dr Fu‐She Han |
| Institution: | 1. Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, 5625 Renmin Street, Changchun, Jilin 130022 (China);2. The University of Chinese Academy of Sciences, Beijing 100864 (P. R. China);3. Department of Chemistry, Northeast Normal University, Changchun, Jilin 130024 (P. R. China);4. State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian, 116024, (P. R. China) |
| Abstract: | A novel protocol for the Pd‐catalyzed ortho‐arylation of aryl phosphinamide with boronic acid is reported. By using phosphinamide as a new directing group, the reaction proceeds efficiently under mild conditions at 40 °C. Mechanistic studies reveal that the reaction proceeds via a PdII to Pd0 cycle. The phosphinamide group is also shown to be an effective orienting group for direct C?H amination. |
| Keywords: | amination arylation C H functionalization palladium phosphinamide |