Enantioseparation using sulfated cyclosophoraoses as a novel chiral additive in capillary electrophoresis |
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| Authors: | Park Heylin Lee Sanghoo Kang Simook Jung Yunjung Jung Seunho |
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| Affiliation: | Department of Advanced Fusion Technology, Bio/Molecular Informatics Center, Konkuk University, Seoul, South Korea. |
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| Abstract: | Highly sulfated cyclosophoraoses (HS-Cys) were synthesized by the chemical modification of a family of neutral cyclosophoraoses isolated from Rhizobium leguminosarum bv. trifolii. The HS-Cys were then analytically characterized using Fourier transform-infrared spectroscopy and elemental analysis. These HS-Cys were successfully used as a novel chiral additive, in low-pH aqueous background electrolytes, for capillary electrophoretic separation of five basic chiral drugs such as arterenol, atenolol, isoproterenol, propranolol, and metoprolol. |
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