Poly(<Emphasis Type="SmallCaps">l</Emphasis>-lactide) networks with tailored water sorption |
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Authors: | Jorge Luis Escobar Ivirico Manuel Salmerón-Sánchez José Luis Gómez Ribelles Manuel Monleón Pradas |
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Institution: | (1) Center for Biomaterials and Tissue Engineering, Universidad Politécnica de Valencia, 46022 Valencia, Spain;(2) Centro de Investigación Príncipe Felipe, Autopista del Saler 16, 46013 Valencia, Spain;(3) Networking Research Center on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), 46022 Valencia, Spain |
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Abstract: | A poly(l-lactide) diol was obtained through ring opening polymerization of l-lactide, using 1,6 hexanediol and tin(II) 2 ethylhexanoate as a catalyst. In the second step, the poly(l-lactide) macromer (mLA) was obtained by the reaction of poly(l-lactide) diol with methacrylic anhydride. The effective incorporation of the polymerizable end groups was assessed by Fourier
transform infrared spectroscopy and nuclear magnetic resonance (1H NMR). Besides, poly(l-lactide) networks (pmLA) were prepared by photopolymerization of mLA. Further, the macromer was copolymerized with 2-hydroxyethyl
acrylate seeking to tailor the hydrophilicity of the system. A set of hydrophilic copolymer networks were obtained. The phase
microstructure of the new system and the network architecture was investigated by differential scanning calorimetry, infrared
spectroscopy, dynamic mechanical spectroscopy, thermogravimetry, and water sorption studies. |
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Keywords: | Hydrogels Macromers l-Lactide) diol" target="_blank">p(l-Lactide) diol Copolymer networks |
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