Enantioselective addition of a chiral thiazolidinethione-derived titanium enolate to acetals |
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| Authors: | Cosp A Romea P Talavera P Urpí F Vilarrasa J Font-Bardia M Solans X |
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| Affiliation: | Departaments de Química Orgànica and Cristal.lografia, Mineralogia i Dipòsits Minerals, Universitat de Barcelona, Catalonia, Spain. |
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| Abstract: | [reaction: see text] High stereoselectivities (up to 98% de) have been achieved for the Lewis acid-mediated cross-coupling reaction of dimethyl acetals to a chiral 1,3-thiazolidine-2-thione-derived titanium enolate. The reaction affords enantiopure anti alpha-methyl-beta-alkoxy carbonyl compounds in a wide range of acetals. |
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