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Unwinding of DNA polymerases by the antitumor drug,cis-diamminedichloroplatinum(II) |
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| Authors: | Volckova Erika Evanics Ferenc Yang Wei W Bose Rathindra N |
| Affiliation: | Department of Chemistry, School of Biomedical Sciences, Kent State University, Kent, OH 44242, USA. |
| Abstract: | The helix-turn-helix motifs of the DNA binding domains of human polymerase-alpha and polymerase-kappa are dramatically perturbed upon binding to cisplatin with concomitant release of zinc. |
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