| 草酸钙的结晶动力学及不同种类羧酸盐的影响 |
| |
| 引用本文： | 李君君,杨 锦,夏志月,欧阳健明. 草酸钙的结晶动力学及不同种类羧酸盐的影响[J]. 无机化学学报, 2012, 28(6): 1091-1098 |
| |
| 作者姓名： | 李君君 杨 锦 夏志月 欧阳健明 |
| |
| 作者单位： | 1. 广东药学院药科学院,广州510006;暨南大学生物矿化与结石病防治研究所,广州 510632
2. 暨南大学生物矿化与结石病防治研究所,广州,510632 |
| |
| 基金项目： | 国家自然科学基金，广东省科技攻关课题 |
| |
| 摘 要： | 通过检测体系中游离Ca2+离子浓度及草酸钙(CaOxa)的粒径随时间的变化,研究了CaOxa的结晶动力学及3种羧酸盐对CaOxa结晶动力学的影响,这些羧酸盐为:一元羧酸盐甘氨酸钠(NaGlu)、二元羧酸盐酒石酸钠(Na2Tart)和三元羧酸盐柠檬酸三钠(Na3Cit)。在生理盐水中CaOxa的结晶动力学方程为r=kc3.3±0.3,平均反应速率常数(k)为(3.1±1.8)×109;3种抑制剂对k的影响程度从大到小为:Na3Cit>Na2Tart>NaGlu,但其平均反应级数(α)相差不大,α=3.2±0.1。Na3Cit、Na2Tart可抑制CaOxa晶体的生长和聚集过程,是潜在的肾结石抑制剂。
|
| 关 键 词： | 草酸钙 结晶动力学 羧酸盐 反应级数 ζ电位 |
Crystallization Kinetics of CaOxa and the Influence of Different Carboxylic Acid Salt |
| |
| LI Jun-Jun,YANG Jin,XIA ZHI-Yue and OUYANG Jian-Ming. Crystallization Kinetics of CaOxa and the Influence of Different Carboxylic Acid Salt[J]. Chinese Journal of Inorganic Chemistry, 2012, 28(6): 1091-1098 |
| |
| Authors: | LI Jun-Jun YANG Jin XIA ZHI-Yue OUYANG Jian-Ming |
| |
| Affiliation: | College of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, China; Institute of Biomineralization and Lithiasis Research, Jinan University, Guangzhou 510632, China,Institute of Biomineralization and Lithiasis Research, Jinan University, Guangzhou 510632, China,Institute of Biomineralization and Lithiasis Research, Jinan University, Guangzhou 510632, China and Institute of Biomineralization and Lithiasis Research, Jinan University, Guangzhou 510632, China |
| |
| Abstract: | The kinetics of calcium oxalate(CaOxa) crystallization and the effect of three carboxylates were studied by determining the changes of free Ca2+ ions concentration and the size of CaOxa crystallites with the reaction time.These carboxylates were monocarboxylic acid salt(NaGlu),dicarboxylic acid salt(Na2Tart),and tricarboxylic acid salt(Na3Cit),respectively.The dynamics equations of calcium oxalate crystallization in normal saline was r=kc3.3±0.3,the average reaction rate constant(k) was(3.1±1.8)×109.The effect of three inhibitors on k values was in the order from large to small: Na3Cit>Na2Tart>NaGlu>blank.However,there is little difference for the average reaction order(α) value and α=3.2±0.1.Since Na3Cit and Na3Tart can inhibit the growth and aggregation of CaOxa crystals,they may be potential inhibitors for formation of kidney stones. |
| |
| Keywords: | calcium oxalate crystallization kinetics carboxylate reaction order ζ potential |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
| 点击此处可从《无机化学学报》浏览原始摘要信息 |
|
点击此处可从《无机化学学报》下载全文 |
|
