Heme CD as a probe for monitoring local structural changes in hemeproteins: Alkaline transition in hemeproteins |
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| Authors: | Tapan K Das Shyamalava Mazumdar and Samaresh Mitra |
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| Institution: | (1) Chemical Physics Group, Tata Institute of Fundamental Research, Homi Bhabha Road, 400005 Navynagar, Bombay, India |
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| Abstract: | Structural change due to acid-alkaline transition in hemeproteins were monitored by circular dichroism measurements in the
Soret region. It was observed that in cytochrome c and horseradish peroxidase, alkaline transition results in a large change
in the heme CD due to significant conformational change in the heme cavity region. In metmyoglobin a simple protolytic mechanism
associated with alkaline transition involves very small conformational changes. |
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| Keywords: | Hemeproteins circular dichroism alkaline transition cytochrome c horseradish peroxidase |
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