Copper(II) complexes of the antihypertensive drug nadolol |
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Authors: | Valentina T Getova Ivayla N Pantcheva Darvin S Ivanov Dimitar R Mehandjiev Vassil Skumryev Panayot R Bontchev |
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Institution: | 1. Faculty of Chemistry, Sofia University, Sofia 1164, Bulgaria 2. Faculty of Pharmacy, Medical University — Sofia, Sofia, 1000, Bulgaria 3. Institute of General and Inorganic Chemistry, Bulgarian Academy of Sciences, Sofia, 1113, Bulgaria 4. Institució Catalana de Recerca i Estudis Avan?ats (ICREA) and Universitat Autònoma de Barcelona, 08193, Bellaterra (Barcelona), Spain
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Abstract: | The complexation of the non-selective β-blocker nadolol, HL, 1 with copper(II) leads to formation of mono-and dinuclear complexes depending mainly on the metal-to-ligand molar ratio. The
mononuclear violet complex CuL2·2Solv, 2, was obtained in a soluble form at metal-to-ligand molar ratio Cu(II): HL ≤ 1: 10 in methanolic or slightly alkaline aqueous
solutions. The dinuclear green complex Cu2L2Cl2·H2O, 3 was synthesized at Cu(II): HL ≥ 1: 2 molar ratio in methanolic solutions. The complexes were studied using spectral (UV-Vis,
FT-IR, EPR), magnetochemical, thermogravimetric methods and elemental analysis. In the complexes nadolol acts as a monoanionic
bidentate ligand coordinated to copper(II) through the NH-and the deprotonated OH-groups of its aminoalcohol fragment.
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Keywords: | Copper(II) complexes nadolol β -blocker |
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