|
|||||
|
|
Synthesis and characterization of 7-(CH3)3N-4- {2,4-(NO2)2C6H3S}-nido-7-CB10H11 and its Biodistribution in C57B16 Mice Bearing B16 Melanoma |
|
| Authors: | John H Morris Gavin S Peters Elena Koldaeva Raisa Spryshkova Gergy Borisov |
| Abstract: | 7-(CH3)3N-4-{2,4-(NO2)2C6H3S}-nido-7-CB10H11 has been synthesized through a Friedel-Crafts substitution reaction on 7-(CH3)3N-nido-7- CB10H12. A biodistribution study in mice with implanted B16 melanoma indicates that the compound locates in neoplastic tissue at concentrations which suggest that its use in 10B neutron capture therapy may be feasible. |
| Keywords: | carbaborane carborane neutron capture therapy melanoma biodistribution boron |