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| 手性膦过渡金属配合物催化不对称交叉偶联反应的研究 | |
| 引用本文： | 王智贤,陈钟瑛. 手性膦过渡金属配合物催化不对称交叉偶联反应的研究[J]. 有机化学, 1993, 13(5): 496-500 |
| 作者姓名： | 王智贤 陈钟瑛 |
| 作者单位： | 华东化工学院化学制药研究室，华东化工学院化学制药研究室 上海，200237，上海，200237 |
| 摘 要： | 自1973年Consiglio和Botteghi首次报道用(一)-DIOP的NiCl_2配合物催化芳基或乙烯基卤代物与仲烷基卤化镁交叉偶联生成光学活性的偶联产物以来,化学家们对不对称交叉偶联反应进行了深入研究。Hayashi等用手性二茂铁膦和手性β-氨基烷基膦的NiCl_2和PdCl_2配合物催化1-苯基乙基氯化 |
| 关 键 词： | 配体 交叉偶联反应 不对称 立体选择性 过渡金属络合物 手性膦 |
Studies of asymmetric cross-coupling reaction catalyzed by chiral phosphine-transition metal complexes |
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| WANG Zhi-Xian,CHENG Zhong-Yin Laboratory of Pharmaceutics,East China University of Chemical Technology, Shanghai. Studies of asymmetric cross-coupling reaction catalyzed by chiral phosphine-transition metal complexes[J]. Chinese Journal of Organic Chemistry, 1993, 13(5): 496-500 | |
| Authors: | WANG Zhi-Xian CHENG Zhong-Yin Laboratory of Pharmaceutics East China University of Chemical Technology Shanghai |
| Affiliation: | WANG Zhi-Xian,CHENG Zhong-Yin Laboratory of Pharmaceutics,East China University of Chemical Technology,200237 Shanghai |
| Abstract: | Ferrocenylphosphine-PdCl_2 and 1, 2-bis (diphenylphosphine)-ethane-NiCl_2 com-plexes catalyzed Grignard cross-coupling of aryl bromide (1a-c) and sec-butylmagnesium bro-mide (2) with high yield and low to medium optical yield. The influences of reaction temperatureand different pare-substituents on aryl bromide (1a-c) were studied, the structure of isomerswas established by GC-MS analysis. |
| Keywords: | Ligand Chiral phosphine Transition metal catalyst Asymmetric cross-coupling Stereoselective synthesis |
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