| Abstract: | The Michael reaction of chiral imines under neutral conditions has emerged as an efficient method for the elaboration of quaternary carbon centers in the alpha position relative to a carbonyl group. It was established early on that this reaction could be accelerated by thermal activation without altering its remarkable features, namely its high regio- and stereoselectivities, Michael adducts being obtained typically in high yield and with 90–98% ee. In this article, a comparative study of high-pressure activation versus thermal, microwave or catalytic activation of this reaction will be reported, highlighting the specificity of each activation mode. |
