Total synthesis of ingenol |
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| Authors: | Nickel Andrew Maruyama Toru Tang Haifeng Murphy Prescott D Greene Blake Yusuff Naeem Wood John L |
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| Institution: | Sterling Chemistry Laboratory, Department of Chemistry, Yale University, New Haven, Connecticut 06520-8107, USA. |
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| Abstract: | A total synthesis of the biologically important diterpene ingenol has been completed. Ring-closing olefin metathesis was used to construct the strained "inside-outside" tetracyclic skeleton, and a series of diastereoselective reactions were employed to complete the synthesis. Another naturally occurring ingenane, 20-deoxyingenol, has also been prepared. |
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