INHIBITION OF Herpes virus PLAQUING CAPACITY IN HUMAN DIPLOID FIBROBLASTS TREATED WITH GILVOCARCIN V PLUS NEAR UV RADIATION |
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| Authors: | L. E. Bockstahler R. K. Elespuru V. M. Hitchins P. G. Carney K. M. Olvey C. D. Lytle |
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| Affiliation: | Office of Science and Technology, Center for Devices and Radiological Health, Food and Drug Administration, Rockville, MD 20857. |
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| Abstract: | The capacity of human fibroblasts to support plaque formation by Herpes simplex virus following treatment of the cells with gilvocarcin V, a polyaromatic C-glycoside, plus near ultraviolet radiation (UVA, 320-400 nm) was examined. Gilvocarcin V, plus UVA radiation, effectively inhibited host cell capacity at concentrations five orders of magnitude lower than that of 8-methyoxypsoralen required for capacity inhibition at similar levels of UVA radiation. This result extends the observation of unusual biological potency of UVA-activated gilvocarcins from bacterial cells to human cells. |
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