| 手性固定相正相高效液相色谱法拆分普萘洛尔对映体 |
| |
| 引用本文： | 赵静,邹卫,赵华,靳红卫.手性固定相正相高效液相色谱法拆分普萘洛尔对映体[J].光谱实验室,2011,28(1):7-11. |
| |
| 作者姓名： | 赵静 邹卫 赵华 靳红卫 |
| |
| 作者单位： | 重庆医科大学药物工程研究中心,重庆市渝中区医学院路1号,400016 |
| |
| 摘 要： | 建立了手性固定相正相高效液相色谱拆分普萘洛尔对映体的方法,考察普萘洛尔对映体在4种多糖类手性色谱柱(Chiralpak AD柱、Chiralcel OD柱、Cniralcel OJ柱和Chiralpak AS柱)(Daicel,250mm×4.6mm,10μm)上的分离行为,同时考察了流动相中醇类以及碱性添加剂二乙胺(...
|
| 关 键 词： | 手性固定相 正相高效液相色谱法 普萘洛尔对映体 |
Resolution of Propranolol Enantiomers by Chiral Solid-Station Phase and NP-HPLC |
| |
| ZHAO Jing ZOU Wei ZHAO Hua JIN Hong-Wei.Resolution of Propranolol Enantiomers by Chiral Solid-Station Phase and NP-HPLC[J].Chinese Journal of Spectroscopy Laboratory,2011,28(1):7-11. |
| |
| Authors: | ZHAO Jing ZOU Wei ZHAO Hua JIN Hong-Wei |
| |
| Institution: | ZHAO Jing ZOU Wei ZHAO Hua JIN Hong-Wei(Pharmaceutical Engineering Research Center,Chongqing Medical University,Chongqing 400016,P.R.China) |
| |
| Abstract: | The resolution of propranolol enantiomers was established by normal-phaseHPLC using chiral solid-station phase.The influences of four polysaccharide chiral columns（Chiralpak AD,Chiralcel OD,Cniralcel OJ,Chiralpak AS）（Daicel,250mm×4.6mm,10μm）,alcohol modifier as well as alkaline modifier diethylamine on propranolol were studied.It was found that propranolol enantiomers were achieved baseline separation on Chiralpak AD,Chiralcel OD and Chiralcel OJ columns,and R-（＋）-propranolol was always first eluted,but there was no serparation on Cniralpak AS column. |
| |
| Keywords: | Chiral Solid-Station Phase Normal-Phase HPLC Propranolol Enantiomers |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
