A Dipolar Anthracene Dye: Synthesis,Optical Properties and Two‐photon Tissue Imaging |
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| Authors: | Dr. Hyunsoo Moon Yong Woong Jun Dr. Dokyoung Kim Hye Gun Ryu Taejun Wang Prof. Dr. Ki Hean Kim Dr. Youngbuhm Huh Prof. Dr. Junyang Jung Prof. Dr. Kyo Han Ahn |
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| Affiliation: | 1. Department of Chemistry, Pohang University of Science and Technology (POSTECH), Pohang, Gyungbuk, Republic of Korea;2. Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA, USA;3. Division of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology (POSTECH), Pohang, Gyungbuk, Republic of Korea;4. Department of Anatomy and Neurobiology, Kyung Hee University, School of Medicine, Biomedical Science Institute, Seoul, Republic of Korea |
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| Abstract: | Two‐photon microscopy is a powerful tool for studying biological systems. In search of novel two‐photon absorbing dyes for bioimaging, we synthesized a new anthracene‐based dipolar dye (anthradan) and evaluated its two‐photon absorbing and imaging properties. The new anthradan, 9,10‐bis(o‐dimethoxy‐phenyl)‐anthradan, absorbs and emits at longer wavelengths than acedan, a well‐known two‐photon absorbing dye. It is also stable under two‐photon excitation conditions and biocompatible, and thus used for two‐photon imaging of mouse organ tissues to show bright, near‐red fluorescence along with negligible autofluorescence. Such an anthradan thus holds promise as a new class of two‐photon absorbing dyes for the development of fluorescent probes and tags for biological systems. |
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| Keywords: | anthracene bioimaging dipolar dyes red-emitting dyes two-photon |
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