Antiviral agents of plant origin. II. Antiviral activity of scopadulcic acid B derivatives |
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| Authors: | T Hayashi K Hayashi K Uchida S Niwayama N Morita |
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| Institution: | Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, Japan. |
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| Abstract: | Scopadulcic acid B derivatives were synthesized and their antiviral activities against herpes simplex virus type 1 (HSV-1) were examined. All the derivatives synthesized showed lower inhibitory activities against HSV-1 than scopadulcic acid B (2). Five compounds, 7, 8, 15, 16, and 18, however, had in vitro therapeutic indexes larger than 7 and were considered to merit further investigation. |
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