Antiplasmodial and cytotoxic activities of drimane sesquiterpenes from Canella winterana |
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| Authors: | Grace Mary H Lategan Carmen Mbeunkui Flaubert Graziose Rocky Smith Peter J Raskin Ilya Lila Mary Ann |
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| Institution: | Plants for Human Health Institute, Department of Food Bioprocessing & Nutrition Sciences, North Carolina State University, 600 Laureate Way, Kannapolis, NC 28081, USA. |
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| Abstract: | The hexane extract from the leaves of Canella winterana exhibited strong activity against the chloroquine sensitive (CQS) strain of Plasmodium falciparum (D10) in vitro (IC50 2.53 microg/mL). Bioassay guided fractionation of this extract has led to the isolation of 5 drimane-type sesquiterpenoids: 9-epideoxymuzigadial, 9-deoxymuzigadial, muzigadial, 3-beta-acetoxypolygodial and the newly isolated hemiacetal, named muzigodiol, with IC50-values of 1.01, 2.19, 0.31, 2.77 and 7.43 microg/mL, respectively. The first four compounds were tested for their cytotoxicity using Chinese Hamster Ovarian (CHO) cells, where they showed IC50-values of 1.82, 33.69, 1.18, and 58.31 microg/mL, respectively. A structure-activity relationship is discussed. |
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