2-Chloro-3-quinolinecarboxaldehyde in the Synthesis of Condensed Quinoline Systems. 1. Synthesis of Derivatives of 3,4-Dihydro-2H-[1,3]thiazino[6,5-b]quinolines |
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Authors: | P V Kombarov M A Yurovskaya |
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Institution: | (1) ASINEKS, Moscow, 123182, Russia;(2) M. V. Lomonosov Moscow State University, Moscow, 119234, Russia |
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Abstract: | A method for the synthesis of derivatives of previously unknown heterocyclic systems - 3,4-dihydro-2H-1,3]thiazino6,5-b]quinolines - has been developed based on 7,8-dimethyl-2-chloro-3-quinolinecarboxaldehyde via the consecutive steps of conversion into its Schiff's base with a primary amine, reduction to the corresponding aminomethyl derivative, conversion to the thiourea with isothiocyanates, and heterocyclization by intramolecular substitution of the chlorine atom. |
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Keywords: | 3 4-dihydro-2H-[1 3]thiazino[6 5-b]quinolines 2-methoxyethylamine Schiff's base thiourea intramolecular nucleophilic cyclization |
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