Copper-catalyzed alkene arylation with diaryliodonium salts |
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Authors: | Phipps Robert J McMurray Lindsay Ritter Stefanie Duong Hung A Gaunt Matthew J |
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Institution: | Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, United Kingdom. |
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Abstract: | Alkenes and arenes represent two classes of feedstock compounds whose union has fundamental importance to synthetic organic chemistry. We report a new approach to alkene arylation using diaryliodonium salts and Cu catalysis. Using a range of simple alkenes, we have shown that the product outcomes differ significantly from those commonly obtained by the Heck reaction. We have used these insights to develop a number of new tandem and cascade reactions that transform readily available alkenes into complex arylated products that may have broad applications in chemical synthesis. |
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