Recent synthetic approaches to oseltamivir phosphate (Tamiflu™) for the treatment of influenza |
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| Authors: | Javier Magano Author Vitae |
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| Affiliation: | Pfizer Inc., Eastern Point Road, Groton, CT 06340, USA |
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| Abstract: | |
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| Keywords: | AAA, asymmetric allylic alkylation Ac, acetyl Boc, tert-Butoxycarbonyl t-Bu3tPy, 4,4&prime ,4&Prime -Tri-tert-butyl-2,2&prime ,6&prime ,2&Prime -terpyridine Cod, Cyclooctadienyl CSA, Camphorsulfonic acid DBU, 1,8-Diazabicyclo[5.4.0]undec-7-ene DCE, 1,2-Dichloroethane DDQ, 2,3-Dichloro-5,6-dicyano-p-benzoquinone DEAD, Diethyl azodicarboxylate DIAD, Diisopropyl azodicarboxylate DIBAL-H, Diisobutylaluminum hydride DIPEA, Diisopropylethylamine DMAP, 4-Di(methylamino)pyridine DMF, N,N-Dimethylformamide DMP, Dess-Martin periodinane DMPU, 1,3-Dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone DMSO, Dimethylsulfoxide Dppf, 1,1&prime -Bis(diphenylphosphino)ferrocene dr, diastereomeric ratio EDCl, N-(3-Dimethylaminopropyl)-N&prime -ethylcarbodiimide hydrochloride ee, enantiomeric excess Esp, α,α,α&prime ,α&prime -Tetramethyl-1,3-benzenedipropionic acid HMDS, Hexamethyldisilazide HMPA, Hexamethylphosphoramide HPLC, high performance liquid chromatography IBX, 2-Iodoxybenzoic acid IPr, 1,3-Bis(2,6-diisopropylphenyl)imidazol-2-ylidene LAH, Lithium aluminum hydride LDA, Lithium diisopropylamide m-CPBA, m-Chloroperbenzoic acid MEIM, N-Methylimidazole Mes, Mesityl MOM, Methoxymethyl Ms, Methanesulfonyl MTBE, tert-Butyl methyl ether MW, microwave NMO, 4-Methylmorpholine N-oxide Ns, p-Nitrobenzenesulfonyl PCC, Pyridinium chlorochromate PDC, Pyridinium dichromate PG, protecting group PMB, p-Methoxybenzyl PPTS, Pyridine p-toluenesulfonate Py, Pyridine SES, 2-(Trimethylsilyl)ethanesulfonyl TBAF, Tetrabutylammonium bromide TBDMS, tert-Butyldimethylsilyl TBS, tert-Butyldimethylsilyl TCCA, Trichlorocyanuric acid TEA, Triethylamine TEMPO, (2,2,6,6-Tetramethyl-piperidin-1-yl)oxyl Tf, Trifluoromethanesulfonyl TFA, Trifluoroacetic acid THF, Tetrahydrofuran TMS, Trimethylsilyl Ts, p-Toluenesulfonyl |
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