含1-[二-(4-氟苯)甲基]哌嗪均三氮唑环的Mannich碱的合成及表征

微波辐射下,在冰醋酸中,3-甲基-4-氨基-1,2,4-三氮唑-5-硫酮1与芳香醛经微波辐射制得相应的中间体Schiff碱2(a~j),然后中间体2与1-二-(4-氟苯)甲基]哌嗪于室温反应制得10个新的Mannich碱3(a~j).合成的10个目标化合物通过熔点测定和质谱、红外光谱、核磁共振氢谱分析、元素分析对其结构进行确证。

Synthesis and characterization of 1-[bi-(4-fluorophenyl)-methyl]piperazine substituted 1,2,4-triazole Mannich base

Ten Mannich bases 3(a-j)were synthesized in this paper.Firstly under microwave irradiation conditions,4,5-dihydro-3-methyl-4-amino-1,2,4-triazole-5-thione 1 reacted with substituted benzaldehyde in acetic acid to form the key intermediate 2(a -j).Then the target compounds 3(a-j)were synthesized by the condensation between 1-bi-(4-fluorophenyl)-methyl]piperazine and the intermediates 2(a-j) in ethanol at room temperature.The structures of target compounds 3(a-j)were confirmed by IR,~1 H NMR,MS spectra and elemental analysis.